We wish to understand the detailed molecular events that underlie the recruitment and regulation of chromatin-modifying complexes by their co‐factor proteins, RNAs and DNA.
Our current focus is on polycomb-group proteins, which mainly appear as histone modifier complexes. These enzymatic complexes, termed polycomb repressive complexes, are required in order to maintain the repressed epigenetic state of thousands of genes during cell differentiation and thus keep genes "off" as long as their products are not needed.
Dysregulation of Polycomb group proteins leads and contribute to the progression of diseases, including various types of cancer and congenital growth disorders. We seek to understand, down to atomic resolution, how the function of these chromatin-modifying complexes is modulated by their various binding partners on chromatin and their cellular environment.